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Image Search Results
Journal: The Journal of General Physiology
Article Title: Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels
doi: 10.1085/jgp.201310998
Figure Lengend Snippet: Domain-specific charge neutralizations. (A) Sequence alignments of the S4 voltage-sensing segments from each domain in Nav1.4. Mutations are marked in bold. (B) A representative family of ionic current traces for wild-type and mutant channels in response to 30-ms depolarizing pulses from −110 to 65 mV (10-mV steps), preceded by a 20-ms prepulse to −120 mV from a holding potential of −80 mV. (C) Normalized peak G-V relationship for wild-type and mutant channels. Solid lines are single Boltzmann fits to the mean for each construct (wild type: V 1/2 = −23.8 mV and z = 5.8 e − ; DI-CN: V 1/2 = −36.5 mV and z = 3.8 e − ; DII-CN: V 1/2 = −25.1 mV and z = 3.3 e − ; DIII-CN: V 1/2 = −26.4 mV and z = 3.9 e − ; DIV-CN: V 1/2 = −23.1 mV and z = 3.8 e − ).
Article Snippet:
Techniques: Sequencing, Mutagenesis, Construct
Journal: The Journal of General Physiology
Article Title: Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels
doi: 10.1085/jgp.201310998
Figure Lengend Snippet: DIV voltage-sensor movement is sufficient for fast inactivation. (A) A representative family of current traces in response to a 30-ms test pulse to −30 mV to assay the fraction of non–steady-state inactivated channels after a 100-ms conditioning prepulse between −170 and 50 mV. See Results for a detailed description of the voltage-pulse protocol. (B) Normalized steady-state inactivation versus conditioning prepulse voltage for wild-type and mutant channels. Solid lines are single Boltzmann fits to the mean for each construct (wild type: V 1/2 = −62.3 mV and z = 4.7 e − ; DI-CN: V 1/2 = −69.2 mV and z = 4.2 e − ; DII-CN: V 1/2 = −65.8 mV and z = 3.7 e − ; DIII-CN: V 1/2 = −68.7 mV and z = 2.7 e − ; DIV-CN: V 1/2 = −137.3 mV and z = 1.1 e − ). Note that the relation does not saturate above −200 mV for DIV-CN, so the observed left-shift in the steady-state inactivation versus voltage relation reflects the minimum shift conferred by this mutant.
Article Snippet:
Techniques: Mutagenesis, Construct
Journal: Reviews in Mineralogy and Geochemistry
Article Title: Lattice Boltzmann-Based Approaches for Pore-Scale Reactive Transport
doi: 10.2138/rmg.2015.80.12
Figure Lengend Snippet: Figure 5. Crystal structures developed at different Da numbers and at solute saturation (1.2): (a) Da = 600; (b) Da = 150; (c) Da = 48; (d) Da = 2. m represents the number of solid particles (crystal mass). [Used by permission of John Wiley and Sons, from Kang Q, Zhang D, Lichtner PC, Tsimpanogiannis IN (2004) Lattice Boltzmann model for crystal growth from supersaturated solution. Geophysical Research Letters, Vol. 31, Fig. 2, p. L21604-3]
Article Snippet: J Comput Phys 250: 293–307 Tong ZX, He YL (2015) A
Techniques:
Journal: Reviews in Mineralogy and Geochemistry
Article Title: Lattice Boltzmann-Based Approaches for Pore-Scale Reactive Transport
doi: 10.2138/rmg.2015.80.12
Figure Lengend Snippet: Figure 6. Crystal structures and solute concentration obtained using single-mineral VOP approach (ran- dom growth) (left) and multiple-mineral VOP approach (right). [Used by permission of Hindawi, from Kang QJ, Lichtner PC (2013) A lattice Boltzmann method for coupled fl uid fl ow, solute transport, and chemical reaction. In: Progress in Computational Physics. Ehrhardt M (ed) Bentham Science Publishers, Vol. 3, Fig. 8, p. 196]
Article Snippet: J Comput Phys 250: 293–307 Tong ZX, He YL (2015) A
Techniques: Concentration Assay